@article{87651,
  keywords = {Animals, Mutation, Transcription Factors, Dosage Compensation, Genetic, DNA-Binding Proteins, Models, Genetic, Female, Male, Chromatin, Drosophila melanogaster, Genes, Lethal, Drosophila Proteins, Genes, Insect, Crosses, Genetic, X Chromosome},
  author = {Anthony Greenberg and Judith Yanowitz and Paul Schedl},
  title = {The Drosophila GAGA factor is required for dosage compensation in males and for the formation of the male-specific-lethal complex chromatin entry site at 12DE.},
  abstract = { Drosophila melanogaster males have one X chromosome, while females have two. To compensate for the resulting disparity in X-linked gene expression between the two sexes, most genes from the male X chromosome are hyperactivated by a special dosage compensation system. Dosage compensation is achieved by a complex of at least six proteins and two noncoding RNAs that specifically associate with the male X. A central question is how the X chromosome is recognized. According to a current model, complexes initially assemble at approximately 35 chromatin entry sites on the X and then spread bidirectionally along the chromosome where they occupy hundreds of sites. Here, we report that mutations in Trithorax-like (Trl) lead to the loss of a single chromatin entry site on the X, male lethality, and mislocalization of dosage compensation complexes. },
  year = {2004},
  journal = {Genetics},
  volume = {166},
  pages = {279-89},
  month = {01/2004},
  issn = {0016-6731},
  language = {eng},
}