@article{87561,
  keywords = {Animals, Base Sequence, Mutation, Promoter Regions, Genetic, Transcription Factors, Chromatin Immunoprecipitation, Protein Binding, DNA-Binding Proteins, Female, Male, Gene Expression Regulation, Developmental, Nuclear Proteins, Embryo, Nonmammalian, Drosophila melanogaster, Genes, Lethal, Reverse Transcriptase Polymerase Chain Reaction, Drosophila Proteins, RNA-Binding Proteins, Basic Helix-Loop-Helix Transcription Factors, Response Elements, Sex Factors, Genes, X-Linked},
  author = {Gretchen Kappes and Girish Deshpande and Brett Mulvey and Jamila Horabin and Paul Schedl},
  title = {The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe.},
  abstract = { The binary switch gene Sex-lethal (Sxl) controls sexual identity in Drosophila. When activated, Sxl imposes female identity, whereas male identity ensues by default when the gene is off. The decision to activate Sxl is controlled by an X chromosome counting system that regulates the Sxl establishment promoter, Sxl-Pe. The counting system depends upon the twofold difference in the gene dose of a series of X-linked transcription factors or numerators. Because of this difference in dose, early female embryos express twice the amount of these transcription factors, and the cumulative action of these transcription factors turns on Sxl-Pe. Here we show that the Drosophila Myc gene diminutive is an X-linked numerator. },
  year = {2011},
  journal = {Proc Natl Acad Sci U S A},
  volume = {108},
  pages = {1543-8},
  month = {01/2011},
  issn = {1091-6490},
  doi = {10.1073/pnas.1017006108},
  language = {eng},
}