@article{203956,
  keywords = {Animals, Transcription, Genetic, Female, Male, Embryo, Nonmammalian, Drosophila melanogaster, Drosophila Proteins, RNA-Binding Proteins, Receptor Protein-Tyrosine Kinases, Intercellular Signaling Peptides and Proteins, Sex Determination Processes},
  author = {Megan Colonnetta and Lauren Lym and Lillian Wilkins and Gretchen Kappes and Elias Castro and Pearl Ryder and Paul Schedl and Dorothy Lerit and Girish Deshpande},
  title = {Antagonism between  and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction},
  abstract = { Transcriptional quiescence, an evolutionarily conserved trait, distinguishes the embryonic primordial germ cells (PGCs) from their somatic neighbors. In , PGCs from embryos maternally compromised for  () misexpress somatic genes, possibly resulting in PGC loss. Recent studies documented a requirement for Gcl during proteolytic degradation of the terminal patterning determinant, Torso receptor. Here we demonstrate that the somatic determinant of female fate,  (), is a biologically relevant transcriptional target of Gcl. Underscoring the significance of transcriptional silencing mediated by Gcl, ectopic expression of a degradation-resistant form of Torso () can activate  transcription in PGCs, whereas simultaneous loss of  () reinstates the quiescent status of  PGCs. Intriguingly, like  mutants, embryos derived from mothers expressing  in the germline display aberrant spreading of pole plasm RNAs, suggesting that mutual antagonism between Gcl and Torso ensures the controlled release of germ-plasm underlying the germline/soma distinction. },
  year = {2021},
  journal = {Elife},
  volume = {10},
  month = {01/2021},
  issn = {2050-084X},
  doi = {10.7554/eLife.54346},
  language = {eng},
}